| Leeds United | 0 - 3 | Chelsea |
| Watford | 0 - 0 | Everton |
| Leicester | 3 - 0 | Norwich |
| Wolves | 1 - 5 | Man thành phố |
| Osasuna | 1 - 1 | Getafe |
| Alaves | 2 - 1 | Espanyol |
| Sevilla | 0 - 0 | Mallorca |
| Elche | 0 - 2 | Atletico |
| Nice | 4 - 2 | St.Etienne |
| Nantes | 2 - 1 | Rennais |
| Juventus | 2 - 4 | Inter |
| Bragantino | 1 - 1 | Atletico MG |
| Ajax | 5 - 0 | SC Heerenveen |
| Cambuur | 1 - 1 | Willem II |
| FC Twente | 3 - 0 | FC Groningen |
| FC Utrecht | 2 - 2 | AZ Alkmaar |
| Fortuna Sittard | 1 - 2 | Vitesse |
| Go Ahead Eagles | 0 - 1 | Feyenoord |
| PSV | 3 - 2 | NEC Nijmegen |
| RKC Waalwijk | 2 - 0 | Heracles |
| Sparta Rotterdam | 2 - 0 | PEC Zwolle |
| Ceara | 2 - 0 | Tombense FC |
| Juazeirense | 1 - 2 | Palmeiras |
| Flamengo | 2 - 0 | Altos |
| Corinthians | 2 - 0 | Portuguesa RJ |
| Vila Nova | 0 - 2 | Fluminense |
| Cuiaba | 0 - 0 | Atletico GO |
| Sivasspor | 1 - 1 | Alanyaspor |
| Misr El-Maqasa | 0 - 2 | Pyramids FC |
| Molde | 3 - 0 | Odds Ballklubb |
| Forge FC | 2 - 0 | Mont-Royal Outremont |
| Vancouver Whitecaps | 2 - 0 | Valour FC |
| Barnechea | 6 - 2 | Deportes Iquique |
| Deportes Recoleta | 2 - 1 | Deportes Temuco |
| Universidad de Concepcion | 0 - 1 | Rangers |
| Deportes Copiapo | 2 - 1 | Santiago Morning |
| FC Lahti | 1 - 1 | HJK |
| KuPS | 2 - 1 | Haka |
| Pakhtakor Tashkent | 2 - 2 | Surkhon-2011 |
| Sogdiyona Jizzax | 1 - 2 | Nasaf Qarshi |
| ADR Jicaral | 2 - 1 | Municipal Perez Zeledon |
| C.S. Cartagines | 3 - 0 | Guanacasteca |
| Santos de Guapiles | 2 - 0 | Grecia |
| Deportivo Saprissa | 1 - 0 | Sporting San Jose |
| Tigres FC | 1 - 2 | Independiente Medellin |
| Bucaramanga | 0 - 0 | La Equidad |
| Once Caldas | 1 - 2 | Atletico Nacional |
| CD Jaguares | 1 - 1 | Millonarios |
| Deportivo Pereira | 1 - 1 | Tolima |
| Santa fe | 0 - 1 | Atletico Junior |
| Union Magdalena | 2 - 1 | America de Cali |
| Nueve de Octubre | 2 - 2 | Guayaquil đô thị |
| Barcelona SC | 1 - 1 | Emelec |
| Olimpia | 1 - 0 | Sol de America |
| Cerro Porteno | 0 - 0 | Guairena |
| Resistencia | 1 - 2 | Guarani |
| Jorge Wilstermann | 1 - 0 | Always Ready |
| Nacional Potosi | 1 - 1 | The Strongest |
| Universitario | 1 - 1 | Oriente Petrolero |
| Servette | 2 - 2 | Lugano |
| Sion | 1 - 3 | Luzern |
| AIK | 2 - 0 | Malmo FF |
| Saburtalo | 0 - 0 | Dinamo Batumi |
| Dila Gori | 0 - 1 | Dinamo Tbilisi |
| Samtredia | 2 - 1 | FC Rustavi |
| WIT Georgia Tbilisi | 1 - 3 | FC Shukura Kobuleti |
| Koper | 3 - 1 | NK Bravo |
| IBV Vestmannaeyjar | 1 - 2 | KR Reykjavik |
| Breidablik | 3 - 2 | Stjarnan |
| KA Akureyri | 1 - 0 | FH Hafnarfjordur |
| Valur | 4 - 0 | IA Akranes |
| CS Universitatea Craiova | 0 - 1 | Sepsi OSK |
| Borac Banja Luka | 1 - 1 | Siroki Brijeg |
| Qarabag | 5 - 0 | Sumqayit |
